The Department of Materials Engineering at the University of Technology awarded the doctoral degree to the student Sally Abdel-Hussein Kazem on her thesis tagged (making a three-dimensional porous polymeric scaffold for bone tissue engineering).
“Fabrication of polymeric composite porous 3D scaffold for bone tissue engineering”
The thesis dealt with bone defects and associated bone diseases as a major challenge in orthopedics. To solve this problem, tissue engineering is one way to promote bone regeneration. Scaffolding is one of the key components of tissue engineering.
This study aims to manufacture new biological nanocomposites based on the mixture of polymers for use in bone scaffolding. Therefore, the scaffold is designed from a three-dimensional porous porous hybrid superposition that simulates the structure and function of the cellular outer hammer of the original tissue.
Attempts were made to develop and manufacture two groups of polymeric mixtures as a biological system through the use of the manual preparation technique. The first group of the polymeric mixture consists of (الإسمX bone cement: PMMA), while the second group samples were prepared from the same materials but in reverse.
Mechanical properties such as (tensioning, bending, shock, hardness and wear) were studied. Microstructure, pore size, and bonding were analyzed by scanning electron microscopy (SEM), Physical analysis by infrared spectroscopy (FTIR) and calorimetric differential survey (DSC), in addition to studying the water absorption and open porosity of all the prepared samples.
Interaction between bone tissue and bone scaffolds manufactured in vivo was evaluated to assess bone regeneration. In vivo study, ten rabbits were used and divided into two equal groups (control and treatment group). In the control group, it included two stages, the first stage, a surgically induced bone defect by removing a length (۸ mm) of all bone tissue thickness and in the second stage, the defect was replaced by the manufactured scaffold and fixed by staping inside the marrow. Whereas, in the treated group, as in the control group, but by automatic bone marrow injection (1 cc) in the cavity and around the scaffold, after 2, 4 and 6 weeks, radiographs were taken after the operation of both groups. The histopathology examination was done 6 weeks after the operation.
The discussion committee consisted of: Dr. Najm Abdul Amir Saeed from the University of Babylon as Chairman and Prof. Bahaa Fakhry Hussein from the University of Baghdad / College of Veterinary Medicine and Prof. Dr. Jawad Kazem Alaiwi and Prof.Dr. Farhad Muhammad Othman and Prof.Dr. Muhammad Abdul-Hussein Muhammad Members and Prof. Dr. Sahama Issa Salih and Prof. Dr. Fadel Abbas Hashem, all of them from the University of Technology and Prof. Muhammad Jawad Issa, a consultant from the University of Baghdad / College of Veterinary Medicine supervisors.