|
Synthesis,
Characterization and Antimicrobil Investigations of (Ag,Cu,Ni,Co,Mn
& Hg)Complexes with Schiff Case Derived from PVA and Erythro-ascorbic
and Derivative |
|
The aim of
this work is the synthesis of new Schiff base derived from PVA
and Erythro-ascorbic acid derivative
(pentulosono-ɣ-lactone-2,3-enedianisoate) and its metal
complexes of biological significance. All synthesized compounds
were characterized by Thin layer chromatography (TLC) and FTIR
spectra and aldehyde was also characterized by (U.V-Vis), 1HNMR,
13CNMR and mass spectra. The synthesized Schiff base & its metal
complexes were screened for theirinvitro antimicrobial activity
against five pathogenic bacteria (Escherichia coli, Shigella
dysentery, Klebsiellapneumonae,
Staphylococcusaureus, Staphylococcus Albus) and two
fungal (Aspergillus Niger,Yeast).The biological activity ofall
complexes is higher than free Schiff base ligand andfollows the
order: polymer < pol-Mn< pol-Ni< pol- Co ˂ pol-Cu ˂ pol-Ag
˂ pol-Hg.This means that metal chelation significantly affects
the antimicrobial behavior of the organic ligand. |
|
