This paper presents a fully integrated system for implanted micro-system devices with efficient power and data transfer based on amplitude shift keying (ASK) modulation techniques. A proposed efficient class-E power amplifier is presented. The design presents a full transcutaneous inductive powering system to transfer power and data from an outside human body to implanted devices such as implanted micro-systems to stimulate and monitor the nerves and muscles with low band frequency of 13.56MHz according to the industrial_scientific_medical (ISM) band to avoid the tissue damage. A novel ASK demodulator powered with 1.9V is proposed with a power recovery system. The modulation index is 13% and the modulation rate7.3% with data rate 1 Mbit/s, and with power efficiency 66%. The system has been designed using 0.35-_m fabricated CMOS technology. The mathematical model is given and the design is simulated using OrCAD PSpice 16.2 software tool and for real-time simulation, the electronic workbench MULISIM 11 has been used to simulate the class-E power amplifier.