Synthesis, Characterization and Antioxidant Studies of Quinazolin Derivatives
Dr.KhalidaAl-Azawi
Abstract

3-((4-(dimethylamino)benzylidene)amino)-2-methylquinazolin-4(3H)-one (3), 3-((4-hydroxybenzylidene)amino)-2-methylquinazolin-4(3H)-one (4), 2-methyl-3-(pyrrolidin-2-ylideneamino)quinazolin-4(3H)-one (5) and 3,3'-((1,4-phenylenebis(methanylylidene)) bis(azanylylidene))bis(2-methylquinazolin-4(3H)-one) (6) derived from 3-amino-2-methylquinazolin-4(3H)-one have been synthesized and characterized by elemental analysis, FT-IR, NMR techniques and screened to establish their potential as antioxidants against 1,1-diphenyl-2-picrylhydrazyl (DPPH) and Nitric oxide (NO) radical scavengers. The results revealed that synthesized compounds (5 and 6) are much higher than common antioxidants ascorbic acid and they showed excellent scavenging capacity against DPPH and Nitric oxide (NO). The synthesized compounds (3 and 4) demonstrated encouraging results comparable with ascorbic acid.
Key words: Antioxidant activity; Avenging activities; 1,1-diphenyl-2-picrylhydrazyl; Nitric oxide.
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